Do these first:

• Install Homebrew

  # In your Mac Terminal, run:
  $ ruby -e "$(curl -fsSL https://raw.github.com/Homebrew/homebrew/go/install)"
  

  # In your ~/.bashrc, ~/.bash_profile, or ~/.zshrc (for zsh users)
  # ...
  export PATH=/usr/local/bin:$PATH
  

  $ brew doctor
  

   [full instructions]
• Install Python 2 and/or 3

  # On Mac >= 10.5 with homebrew
  $ brew update
  ## Install Python 2
  $ brew install python
  ## Install Python 3
  $ brew install python3
  ## Follow any instructions that appear after each brew install
  

  # Is everything working?
  $ brew doctor
  # Listen to the doctor
  

  # Run Python 2
  $ python
  # Run Python 3
  $ python3
  # Install a Python 2 package
  $ pip install some-package
  # Install a Python 3 package
  $ pip3 install some-package
  

   [full instructions]
• Install the latest Mac C and C++ compilers

  # Get the latest version of Xcode from the Mac App Store
  # Here: https://developer.apple.com/xcode/
  

  # Open Xcode, then press `Command + ,` to open preferences
  

  # Click `Downloads` at the top of the window
  # Then click `Install` next to `Command Line Tools`
  

   [full instructions]

Optional (but recommended) first step: Create a new virtual environment

# If you're using virtualenvwrapper
$ mkvirtualenv science
$ workon science

Numpy, Scipy, and Matplotlib

Install a fortran compiler and Freetype.

$ brew update
$ brew install gfortran freetype
# Remember to follow any instructions that show up after each install
# To display the instructions again, run `brew info gfortran` or `brew info freetype`

Install the Python packages.

# Order matters!
$ pip install numpy
$ pip install scipy
$ pip install matplotlib
# Optional: install ipython
$ pip install ipython

If everything works, you should be able to import pylab, which will bring numpy, scipy, and matplotlib functionality all in one go.

# Check that everything works
$ python
>>> import pylab

If all you need is numpy, scipy, and matplotlib, you're done!

Bonus: Install the rest of the EPD packages

If you want to install more of the libraries included with EPD, you can try making a requirements.txt file containing the following:

# requirements.txt
# This includes all the packages bundled with EPD-Free
# Feel free to add/remove any items
appinst>=2.1.1
apptools>=4.1.0
casuarius>=1.0
chaco>=4.2.0
cloud>=2.4.6
configobj>=4.7.2
distribute>=.6.26
enable>=4.2.0
enaml>=0.2.0
enstaller>=4.5.1
etsproxy>=0.1.1
freetype>=2.4.4
ipython>=0.12.1
jinja2>=2.6
libjpeg>=7.0
libpng>=7.0
matplotlib>=1.1.0
nose>=1.1.2
numpy>=1.6.1
PIL>=1.1.7
ply>=3.4
pyaudio>=0.2.4
pyface>=4.2.0
pyglet>=1.1.4
pygments>=1.4
python_dateutil>=1.5
pytz
pyzmq>=2.1.11
scipy>=1.74
tornado>=2.2
traits>=4.2.0
traitsui>=4.2.0
wxPython>=2.8.10

Then run:

$ pip install -r -U requirements.txt

NOTE: This step has not been verified. It is possible that some of the packages have other non-Python dependencies that need to be installed first.

See also:

• Enthought Python Distribution
• Installing scientific Python on MacOS X - Lowin Data Company